IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes

Background  We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens. Methods  IgG antibodies were determined by immunoblot and ELISA to streptococc...

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Bibliographic Details
Published in:International journal of dermatology 2004-05, Vol.43 (5), p.341-347
Main Authors: Cancino-Díaz, Mario E., Ruiz-González, Verónica, Ramírez-Reséndiz, Luis, Ortiz, Blanca, Domínguez-López, María Lilia, Paredes-Cabrera, Giovanna C., León-Dorantes, Gladys, Blancas-González, Fernando, Jiménez-Zamudio, Luis, García-Latorre, Ethel
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - analysis
Antigens, Bacterial - immunology
Biological and medical sciences
Case-Control Studies
Dermatology
Enzyme-Linked Immunosorbent Assay
Heat-Shock Proteins - immunology
Humans
Immunoblotting
Immunoglobulin G - analysis
Medical sciences
Psoriasis - immunology
Psoriasis - microbiology
Psoriasis. Parapsoriasis. Lichen
Streptococcus pyogenes - genetics
Streptococcus pyogenes - immunology
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Summary:Background  We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens. Methods  IgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp). Results  We found by immunoblot that the IgG response to 71‐, 60‐, and 14‐kDa protein fractions of Streptococcus pyogenes is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2004.01884.x