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IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes
Background We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens. Methods IgG antibodies were determined by immunoblot and ELISA to streptococc...
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| Published in: | International journal of dermatology 2004-05, Vol.43 (5), p.341-347 |
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| container_title | International journal of dermatology |
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| creator | Cancino-Díaz, Mario E. Ruiz-González, Verónica Ramírez-Reséndiz, Luis Ortiz, Blanca Domínguez-López, María Lilia Paredes-Cabrera, Giovanna C. León-Dorantes, Gladys Blancas-González, Fernando Jiménez-Zamudio, Luis García-Latorre, Ethel |
| description | Background We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens.
Methods IgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp).
Results We found by immunoblot that the IgG response to 71‐, 60‐, and 14‐kDa protein fractions of Streptococcus pyogenes is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (P |
| doi_str_mv | 10.1111/j.1365-4632.2004.01884.x |
| format | article |
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Methods IgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp).
Results We found by immunoblot that the IgG response to 71‐, 60‐, and 14‐kDa protein fractions of Streptococcus pyogenes is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (P < 0.05) with an odds ratio of 11.11 (CI95% of 4.33–28.49). The PP infected with S. pyogenes had higher titers of the antirHSP60Sp, high ASO, and high PASI. The PP patients did not significantly recognize the HSP60Ec or the HSP60Hu. The GP patients had a higher response to the rHSP60Sp than the healthy controls or ISp patients (P < 0.05) but showed no association with the disease. The response of the ISp patients to the HSP60Sp was similar to the healthy controls. The response to the rHSP70Sp was similar in the PP patients and the healthy controls.
Conclusion Results suggest that a high response to the HSP60Sp could be associated with the chronic form of psoriasis.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2004.01884.x</identifier><identifier>PMID: 15117363</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Antibodies, Bacterial - analysis ; Antigens, Bacterial - immunology ; Biological and medical sciences ; Case-Control Studies ; Dermatology ; Enzyme-Linked Immunosorbent Assay ; Heat-Shock Proteins - immunology ; Humans ; Immunoblotting ; Immunoglobulin G - analysis ; Medical sciences ; Psoriasis - immunology ; Psoriasis - microbiology ; Psoriasis. Parapsoriasis. Lichen ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - immunology</subject><ispartof>International journal of dermatology, 2004-05, Vol.43 (5), p.341-347</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. May 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5104-abea7e23e6c4feafc24c09ad85e16f08b3504cce5e633abfbfee8aa17e1507983</citedby><cites>FETCH-LOGICAL-c5104-abea7e23e6c4feafc24c09ad85e16f08b3504cce5e633abfbfee8aa17e1507983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15745859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15117363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cancino-Díaz, Mario E.</creatorcontrib><creatorcontrib>Ruiz-González, Verónica</creatorcontrib><creatorcontrib>Ramírez-Reséndiz, Luis</creatorcontrib><creatorcontrib>Ortiz, Blanca</creatorcontrib><creatorcontrib>Domínguez-López, María Lilia</creatorcontrib><creatorcontrib>Paredes-Cabrera, Giovanna C.</creatorcontrib><creatorcontrib>León-Dorantes, Gladys</creatorcontrib><creatorcontrib>Blancas-González, Fernando</creatorcontrib><creatorcontrib>Jiménez-Zamudio, Luis</creatorcontrib><creatorcontrib>García-Latorre, Ethel</creatorcontrib><title>IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens.
Methods IgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp).
Results We found by immunoblot that the IgG response to 71‐, 60‐, and 14‐kDa protein fractions of Streptococcus pyogenes is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (P < 0.05) with an odds ratio of 11.11 (CI95% of 4.33–28.49). The PP infected with S. pyogenes had higher titers of the antirHSP60Sp, high ASO, and high PASI. The PP patients did not significantly recognize the HSP60Ec or the HSP60Hu. The GP patients had a higher response to the rHSP60Sp than the healthy controls or ISp patients (P < 0.05) but showed no association with the disease. The response of the ISp patients to the HSP60Sp was similar to the healthy controls. The response to the rHSP70Sp was similar in the PP patients and the healthy controls.
Conclusion Results suggest that a high response to the HSP60Sp could be associated with the chronic form of psoriasis.</description><subject>Antibodies, Bacterial - analysis</subject><subject>Antigens, Bacterial - immunology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Dermatology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Heat-Shock Proteins - immunology</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunoglobulin G - analysis</subject><subject>Medical sciences</subject><subject>Psoriasis - immunology</subject><subject>Psoriasis - microbiology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Streptococcus pyogenes - genetics</subject><subject>Streptococcus pyogenes - immunology</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkc2O0zAUhS0EYjoDr4AsJNgl2HEcOwsWaAZKofxIDJql5bg3rTtpHGxH0_L0OLQaECu8sa_8naOjexDClOQ0nVfbnLKKZ2XFirwgpMwJlbLM9w_Q7P7jIZoRQmlWE16fofMQtmlkBS0fozPKKRWsYjPUL9ZzbDodAtZ9tI1bWQi49W6Hh-C81cEGPOhooY8BezBu3dufgOMGcEWyj1cab0DHLGycucWDdxFsj12Lv0UPQ3TGGTMmh4NbQw_hCXrU6i7A09N9gb6_e3t9-T5bfpkvLt8sM8MpKTPdgBZQMKhM2YJuTVEaUuuV5ECrlsiGcVIaAxwqxnTTNi2A1JoKoJyIWrIL9PLomxL9GCFEtbPBQNfpHtwYlKBSVAUtEvj8H3DrRt-nbKooCllzKViC5BEy3oXgoVWDtzvtD4oSNRWitmrau5r2rqZC1O9C1D5Jn538x2YHqz_CUwMJeHECdDC6a73ujQ1_caLkkteJe33k7mwHh_8OoBYfrqZX0mdHvQ0R9vd67W9VJZjg6ubzXImvN-U1_cTVkv0CJ5K25Q</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Cancino-Díaz, Mario E.</creator><creator>Ruiz-González, Verónica</creator><creator>Ramírez-Reséndiz, Luis</creator><creator>Ortiz, Blanca</creator><creator>Domínguez-López, María Lilia</creator><creator>Paredes-Cabrera, Giovanna C.</creator><creator>León-Dorantes, Gladys</creator><creator>Blancas-González, Fernando</creator><creator>Jiménez-Zamudio, Luis</creator><creator>García-Latorre, Ethel</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200405</creationdate><title>IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes</title><author>Cancino-Díaz, Mario E. ; Ruiz-González, Verónica ; Ramírez-Reséndiz, Luis ; Ortiz, Blanca ; Domínguez-López, María Lilia ; Paredes-Cabrera, Giovanna C. ; León-Dorantes, Gladys ; Blancas-González, Fernando ; Jiménez-Zamudio, Luis ; García-Latorre, Ethel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5104-abea7e23e6c4feafc24c09ad85e16f08b3504cce5e633abfbfee8aa17e1507983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antibodies, Bacterial - analysis</topic><topic>Antigens, Bacterial - immunology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Dermatology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Heat-Shock Proteins - immunology</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunoglobulin G - analysis</topic><topic>Medical sciences</topic><topic>Psoriasis - immunology</topic><topic>Psoriasis - microbiology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Streptococcus pyogenes - genetics</topic><topic>Streptococcus pyogenes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cancino-Díaz, Mario E.</creatorcontrib><creatorcontrib>Ruiz-González, Verónica</creatorcontrib><creatorcontrib>Ramírez-Reséndiz, Luis</creatorcontrib><creatorcontrib>Ortiz, Blanca</creatorcontrib><creatorcontrib>Domínguez-López, María Lilia</creatorcontrib><creatorcontrib>Paredes-Cabrera, Giovanna C.</creatorcontrib><creatorcontrib>León-Dorantes, Gladys</creatorcontrib><creatorcontrib>Blancas-González, Fernando</creatorcontrib><creatorcontrib>Jiménez-Zamudio, Luis</creatorcontrib><creatorcontrib>García-Latorre, Ethel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cancino-Díaz, Mario E.</au><au>Ruiz-González, Verónica</au><au>Ramírez-Reséndiz, Luis</au><au>Ortiz, Blanca</au><au>Domínguez-López, María Lilia</au><au>Paredes-Cabrera, Giovanna C.</au><au>León-Dorantes, Gladys</au><au>Blancas-González, Fernando</au><au>Jiménez-Zamudio, Luis</au><au>García-Latorre, Ethel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2004-05</date><risdate>2004</risdate><volume>43</volume><issue>5</issue><spage>341</spage><epage>347</epage><pages>341-347</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background We have previously found that psoriatic patients have IgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens.
Methods IgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp).
Results We found by immunoblot that the IgG response to 71‐, 60‐, and 14‐kDa protein fractions of Streptococcus pyogenes is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (P < 0.05) with an odds ratio of 11.11 (CI95% of 4.33–28.49). The PP infected with S. pyogenes had higher titers of the antirHSP60Sp, high ASO, and high PASI. The PP patients did not significantly recognize the HSP60Ec or the HSP60Hu. The GP patients had a higher response to the rHSP60Sp than the healthy controls or ISp patients (P < 0.05) but showed no association with the disease. The response of the ISp patients to the HSP60Sp was similar to the healthy controls. The response to the rHSP70Sp was similar in the PP patients and the healthy controls.
Conclusion Results suggest that a high response to the HSP60Sp could be associated with the chronic form of psoriasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15117363</pmid><doi>10.1111/j.1365-4632.2004.01884.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies, Bacterial - analysis Antigens, Bacterial - immunology Biological and medical sciences Case-Control Studies Dermatology Enzyme-Linked Immunosorbent Assay Heat-Shock Proteins - immunology Humans Immunoblotting Immunoglobulin G - analysis Medical sciences Psoriasis - immunology Psoriasis - microbiology Psoriasis. Parapsoriasis. Lichen Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology |
| title | IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes |
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