Estrous-cycle-dependent Variation in Orthodontic Tooth Movement

Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used....

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Bibliographic Details
Published in:Journal of dental research 2002-06, Vol.81 (6), p.406-410
Main Authors: Haruyama, N., Igarashi, K., Saeki, S., Otsuka-Isoya, M., Shinoda, H., Mitani, H.
Format: Article
Language:English
Subjects:
Acid Phosphatase - blood
Amino Acids - blood
Analysis of Variance
Animals
Bone Remodeling - physiology
Calcium - blood
Dentistry
Estradiol - blood
Estradiol - secretion
Estrous Cycle - physiology
Female
Isoenzymes - blood
Osteocalcin - blood
Phosphorus - blood
Progesterone - blood
Rats
Rats, Wistar
Statistics, Nonparametric
Tartrate-Resistant Acid Phosphatase
Tooth Movement Techniques
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Summary:Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = -0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910208100610