Increases in Interleukin-6 and Matrix Metalloproteinase-9 in the Infarct-Related Coronary Artery of Acute Myocardial Infarction

• Published in: Circulation Journal 2004, Vol.68(5), pp.451-454
• Main Authors: Funayama, Hiroshi, Ishikawa, San-e, Kubo, Norifumi, Katayama, Takuji, Yasu, Takanori, Saito, Muneyasu, Kawakami, Masanobu
• Format: Article
• Language: English
• Subjects: Acute myocardial infarction; Adult; Aged; Aged, 80 and over; Aorta; Arteries - diagnostic imaging; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary Vessels - diagnostic imaging; Elastic Tissue - diagnostic imaging; Humans; Interleukin-6; Interleukin-6 - blood; Matrix Metalloproteinase 9 - blood; Matrix metalloproteinase-9; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - etiology; Ultrasonography, Interventional; Veins - diagnostic imaging
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.68.451

Background To elucidate the involvement of inflammation in coronary artery occlusion, the regional changes in cytokines and matrix metalloproteinases (MMPs) in the infarct-related coronary artery were determined in patients with acute myocardial infarction. Methods and Results Cardiac catheterization was carried out within 24 h of the onset of infarction in 36 patients. Blood samples were collected from the infarct-related coronary artery, the ascending aorta and the peripheral vein. Plasma interleukin (IL)-6 concentrations were elevated in all 3 samples. Particularly, the plasma IL-6 concentrations were 14.4 pg/ml in the infarct-related coronary artery, a value significantly greater than the respective 8.0 pg/ml and 6.5 pg/ml in the ascending aorta and peripheral vein. Plasma IL-6 concentrations in the infarct-related coronary artery had positive correlation with all of the following references measured by intravascular ultrasound: external elastic membrane cross-sectional area (EEM-CSA) (r=0.47, p