Achievement of pregnancy in globozoospermia with Y chromosome microdeletion after ICSI

Pregnancy achieved with sperm from a patient with globozoospermia is rare, even after ICSI, since the activation of the oocyte may not occur in this disorder. Therefore, activation of the oocytes by piezoelectricity or calcium ionophores has been suggested, although spontaneous activation of the ooc...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2002-07, Vol.17 (7), p.1833-1836
Main Authors: ZEYNELOGLU, Hulusi Bulent, BALTACI, Volkan, DURAN, Hakan Eyup, ERDEMLI, Esra, BATIOGLU, Sertac
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Chromosomes, Human, Y - genetics
Embryo Transfer
Female
Gene Deletion
Gynecology. Andrology. Obstetrics
Humans
In Situ Hybridization, Fluorescence
Male
Medical sciences
Ovulation Induction
Polymerase Chain Reaction
Pregnancy
Sperm Injections, Intracytoplasmic
Spermatozoa - abnormalities
Sterility. Assisted procreation
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Summary:Pregnancy achieved with sperm from a patient with globozoospermia is rare, even after ICSI, since the activation of the oocyte may not occur in this disorder. Therefore, activation of the oocytes by piezoelectricity or calcium ionophores has been suggested, although spontaneous activation of the oocyte after ICSI has been reported in some cases. We report a successful pregnancy in a couple in which the male partner had globozoospermia with microdeletions in the Y chromosome with no further assisted activation after ICSI. During the diagnostic study of the husband, increased numerical chromosome abnormalities after fluorescent in-situ hybridization (FISH) and microdeletions in AZFa; sY86 and AZFb; sY 131 were detected. Out of the 13 oocytes injected, four fertilized and a twin pregnancy was obtained after replacement of four embryos. Healthy twin girls were delivered after a term pregnancy. Some patients with globozoospermia may also have Y chromosome microdeletions, which subsequently may be inherited by the male offspring in cases of achievement of pregnancy.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/17.7.1833