NATIONWIDE SURVEILLANCE OF PARENTERAL ANTIBIOTICS CONTAINING MEROPENEM ACTIVITIES AGAINST CLINICALLY ISOLATED STRAINS IN 2002

• Published in: Japanese journal of antibiotics 2004/02/25, Vol.57(1), pp.70-104
• Main Authors: YAMAGUCHI, KEIZO, ISHIII, YOSHIKAZU, IWATA, MORIHIRO, WATANABE, NAOKI, UEHARA, NOBUYUKI, YASUJIMA, MINORU, KASAI, TACESHI, SUWABE, AKIRA, OBATA, RITSUKO, KAKU, MITSUO, KANEMITSU, KEIJI, YOSHIDA, HIROSHI, SATOH, TOSHIO, MURAKAMI, MASAMI, TAKAHASHI, AYAKO, ISHIGO, SHIOMI, FUJITA, NAOHISA, KOMORI, TOSHIAKI, ICHIYAMA, SATOSHI, MAEDA, SHIGETAKA, YAMANAKA, KIYOHARU, AIHARA, MASANORI, KINOSHITA, SHOHIRO, ITOH, KOUICHI, SHIBUYA, YASUHIRO, KANNO, HARUSIGE, KUBO, SETSUKO, MAESAKI, SIGEFUMI, HASHIKITA, YOSHIKAZU, OGURI, TOYOKO, OKADA, JUN, TAZAWA, YOKO, NAKASHIMA, HIDEKI, TAKEMURA, HIROMU, HORII, TOSHINOBU, BABA, HISASHI, TOMOHIKO, TAMINATO, NEGAYAM, KIYOSHIN, MURASE, MITSUHARU, MIYAMOT, HITOSHI, KUSANO, NOBUCHIKA, MIHARA, EIICHIROU, KAMBE, MASAYUKI, ITAHA, HIDEYUKI, ONO, JUNKO, YOSHIMURA, HISAE, HIRAKATA, YOICHI, MATSUDA, JUNICHI, SAIKAWA, TETSUNORI, HIRAMATSU, KAZUFUMI
• Format: Article
• Language: Japanese
• Subjects: Bacteria - drug effects; Bacteria - isolation & purification; Bacterial Infections - microbiology; Carbapenems - pharmacology; Drug Resistance, Bacterial; Humans; Japan; Product Surveillance, Postmarketing; Thienamycins - pharmacology; Time Factors
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.57.70

The antibacterial activity of meropenem (MEPM) and other parenteral antibiotics against clinical isolates of 899 strains of Gram-positive bacteria, 1500 strains of Gram-negative bacteria, and 158 strains of anaerobic bacteria obtained from 28 medical institutions during 2002 was measured. The results were as follows; 1. MEPM was more active than other carbapenem antibiotics against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MIC90 of MEPM against Pseudomonas aeruginosa was the lowest of the drugs tested. MEPM showed low cross-resistant rate against both imipenem-resistant P. aeruginosa and ciprofloxacin-resistant P. aeruginosa. MEPM was active against most of the species tested in Gram-positive and anaerobic bacteria, except for multi-drug resistant strains including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE). 2. The proportion of extended-spectrum β-lactamase (ESBL) strains was 3.1% (4 strains) in Escherichia coli and 1.9% (2 strains) in Klebsiella pneumoniae. Carbapenems including MEPM were active against these ESBL strains. In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem at present, 7 years after available for commercial use.