Bilateral adrenal hemorrhage in essential thrombocythemia

A 67-year-old woman with previously untreated essential thrombocythemia developed bilateral adrenal hemorrhage. She had no known vascular risk factors including smoking, diabetes mellitus, hypertension, and hypercholesterolemia. Her platelet count was 921 x 10(9)/l. She received preemptive steroid t...

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Bibliographic Details
Published in:Annals of hematology 2002-06, Vol.81 (6), p.350-351
Main Authors: KOJIMA, K, FUJII, N, TAKATA, S, TEZEN, T, MORIKAWA, T, KANEDA, K, TAKENAKA, K, ITOSHIMA, T, TANIMOTO, M
Format: Article
Language:English
Subjects:
Adrenal Gland Diseases - etiology
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Biological and medical sciences
Endocrinopathies
Female
Hematologic and hematopoietic diseases
Hemorrhage - etiology
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thrombocythemia, Essential - complications
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Summary:A 67-year-old woman with previously untreated essential thrombocythemia developed bilateral adrenal hemorrhage. She had no known vascular risk factors including smoking, diabetes mellitus, hypertension, and hypercholesterolemia. Her platelet count was 921 x 10(9)/l. She received preemptive steroid therapy to prevent the occurrence of adrenal crisis, but 5 weeks later the replacement therapy was discontinued because the patient fully recovered with a normal adrenocorticotropic hormone stimulation test. Thereafter, she remained well for more than 4 years with a platelet count ranging from 600 to 800 x 10(9)/l. Although adrenal hemorrhage is very rare, it can occur as a hemorrhagic complication of essential thrombocythemia.
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-002-0468-1