Performance Optimization of Spectroscopic Process Analyzers

To increase the power and the robustness of spectroscopic process analyzers, methods are needed that suppress the spectral variation that is not related to the property of interest in the process stream. An approach for the selection of a suitable method is presented. The approach uses the net analy...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2004-05, Vol.76 (9), p.2656-2663
Main Authors: Boelens, Hans F. M, Kok, Wim Th, de Noord, Onno E, Smilde, Age K
Format: Article
Language:English
Subjects:
Analytical chemistry
Batch processes
Chemistry
Exact sciences and technology
Mass spectrometry
Spectrometric and optical methods
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Summary:To increase the power and the robustness of spectroscopic process analyzers, methods are needed that suppress the spectral variation that is not related to the property of interest in the process stream. An approach for the selection of a suitable method is presented. The approach uses the net analyte signal (NAS) to analyze the situation and to select methods to suppress the nonrelevant spectral variation. The empirically determined signal-to-noise of the NAS is used as a figure of merit. The advantages of the approach are (i) that the error of the reference method does not affect method selection and (ii) that only a few spectral measurements are needed. A diagnostic plot is proposed that guides the user in the evaluation of the particular suppression method. As an example, NIR spectroscopic monitoring of a mol−sieve separation process is used.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac0353987