Can MMTV exploit TLR4?

The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response. A recent publication proposed that the...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2002-07, Vol.10 (7), p.303-305
Main Authors: Otten, Luc A, Finke, Daniela, Acha-Orbea, Hans
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
B-Lymphocytes - virology
Drosophila Proteins
infection
Mammary Tumor Virus, Mouse - immunology
Membrane Glycoproteins - genetics
Membrane Glycoproteins - immunology
Mice
MMTV
Receptors, Cell Surface - genetics
Receptors, Cell Surface - immunology
retrovirus
TLR4
Toll-like receptor
Toll-Like Receptor 4
Toll-Like Receptors
Viral Envelope Proteins - immunology
virus-host interaction
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Summary:The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response. A recent publication proposed that the retrovirus mouse mammary tumor virus exploits the pattern-recognition receptor Toll-like receptor 4 to achieve more efficient infection. Toll-like receptors recognize pathogens and are essential for triggering an efficient immune response. A recent publication proposed that a retrovirus exploits the pattern recognition Toll-like receptor 4.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(02)02385-5