Structural and functional analyses of bacterial lipopolysaccharides

Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infected hosts, and may cause endotoxic shock. Most of them share a common architecture but vary considerably in structural motifs from one genus, species, and strain to another. Cells of the innate immune response recognize evolu...

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Bibliographic Details
Published in:Microbes and infection 2002-07, Vol.4 (9), p.915-926
Main Authors: Caroff, Martine, Karibian, Doris, Cavaillon, Jean-Marc, Haeffner-Cavaillon, Nicole
Format: Article
Language:English
Subjects:
Animals
Bacteria - immunology
Cytokines
Cytokines - immunology
Humans
Immunity, Innate - immunology
Lipopolysaccharide heterogeneity
Lipopolysaccharides - chemistry
Lipopolysaccharides - immunology
Molecular Structure
Monocytes - immunology
Receptor
Shock, Septic - immunology
Signal Transduction
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Summary:Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infected hosts, and may cause endotoxic shock. Most of them share a common architecture but vary considerably in structural motifs from one genus, species, and strain to another. Cells of the innate immune response recognize evolutionarily conserved LPS molecular patterns of endotoxins and structural details thereby greatly influencing their response.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(02)01612-X