Pamidronate induces bone formation in patients with smouldering or indolent myeloma, with no significant anti‐tumour effect

Twelve patients with smouldering or indolent multiple myeloma (MM) received 12 courses of intravenous pamidronate as a single agent to evaluate both the antitumour and bone metabolism effects. One patient achieved minor response, eight had stable disease, and three – all indolent MM – showed disease...

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Bibliographic Details
Published in:British journal of haematology 2002-07, Vol.118 (1), p.239-242
Main Authors: Martín, Alejandro, García‐Sanz, Ramón, Hernández, José, Bladé, Joan, Suquía, Begoña, Fernández‐Calvo, Javier, González, Marcos, Mateo, Gema, Orfao, Alberto, San Miguel, Jesus F.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
bone disease
Bone Remodeling - drug effects
Bones, joints and connective tissue. Antiinflammatory agents
Diphosphonates - therapeutic use
Disease Progression
Female
Follow-Up Studies
Hematology
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
indolent myeloma
Infusions, Intravenous
Male
Medical sciences
Middle Aged
multiple myeloma
Multiple Myeloma - drug therapy
Pamidronate
Pharmacology. Drug treatments
smouldering myeloma
Treatment Failure
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Summary:Twelve patients with smouldering or indolent multiple myeloma (MM) received 12 courses of intravenous pamidronate as a single agent to evaluate both the antitumour and bone metabolism effects. One patient achieved minor response, eight had stable disease, and three – all indolent MM – showed disease progression. Serum interleukin 6 (IL‐6), IL‐1β and Oncostatin‐M remained stable throughout the study, while tumour necrosis factor‐α increased. Bone density significantly increased after four and 12 courses compared with baseline. Markers for bone resorption and bone formation decreased with treatment. These results suggest that pamidronate treatment reduces bone turnover in smouldering or indolent MM, but has no significant antitumour effect.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2002.03549.x