Top-SUMO Wrestles Centromeric Cohesion

Sister chromatid cohesion at the centromere is distinct from cohesion at the chromosome arms. In the June issue of Molecular Cell, Bachant et al. have shown that centromeric cohesion in budding yeast is specifically regulated by SUMO-1 modification of Topoisomerase II.

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Bibliographic Details
Published in:Developmental Cell 2002-07, Vol.3 (1), p.4-6
Main Authors: Pinsky, Benjamin A., Biggins, Sue
Format: Article
Language:English
Subjects:
Animals
Cell Division - physiology
Centromere - metabolism
Chromosome Segregation - physiology
DNA Topoisomerases, Type II - genetics
DNA Topoisomerases, Type II - metabolism
Endopeptidases - genetics
Endopeptidases - metabolism
Eukaryotic Cells - cytology
Eukaryotic Cells - metabolism
Humans
Saccharomycetales - cytology
Saccharomycetales - metabolism
SUMO-1 Protein - genetics
SUMO-1 Protein - metabolism
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Description
Summary:Sister chromatid cohesion at the centromere is distinct from cohesion at the chromosome arms. In the June issue of Molecular Cell, Bachant et al. have shown that centromeric cohesion in budding yeast is specifically regulated by SUMO-1 modification of Topoisomerase II.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(02)00214-9