Vascular endothelial growth factor levels in serum and plasma following esophageal cancer resection: relationship to platelet count

In patients with cancer circulating vascular endothelial growth factor (VEGF) may be tumor-derived and have prognostic significance. Activated platelets may also be a source of VEGF, releasing it in serum formation. Debate exists as to whether serum or plasma VEGF (S-VEGF, P-VEGF) is the most approp...

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Bibliographic Details
Published in:The International journal of biological markers 2002-04, Vol.17 (2), p.119-124
Main Authors: SPENCE, G. M, GRAHAM, A. N. J, MULHOLLAND, K, MCALLISTER, I, SLOAN, J. M, ARMSTRONG, M. A, CAMPBELL, F. C, MCGUIGAN, J. A
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Endothelial Growth Factors - blood
Esophageal Neoplasms - blood
Esophageal Neoplasms - surgery
Esophagectomy
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intercellular Signaling Peptides and Proteins - blood
Investigative techniques, diagnostic techniques (general aspects)
Lymphokines - blood
Male
Medical sciences
Middle Aged
Miscellaneous. Technology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Platelet Count
Tumors
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:In patients with cancer circulating vascular endothelial growth factor (VEGF) may be tumor-derived and have prognostic significance. Activated platelets may also be a source of VEGF, releasing it in serum formation. Debate exists as to whether serum or plasma VEGF (S-VEGF, P-VEGF) is the most appropriate surrogate marker of tumor angiogenesis. As healing wounds produce VEGF that can spill over into the circulation, we aimed to investigate the potential confounding effects of cancer surgery on both perioperative S-VEGF and P-VEGF levels and to evaluate their relationship with platelet count. S-VEGF, P-VEGF and platelet counts were measured in 23 patients undergoing esophageal cancer resection. Samples were taken preoperatively and six weeks following surgery. Seven patients were also sampled on postoperative days 1, 5 and 10. VEGF was assayed using a commercial enzyme linked immunosorbent assay. S-VEGF and P-VEGF both rose after surgery (S-VEGF; day 5: 1017 [446-1224] pg/mL and day 10: 1231 [626-2046] pg/mL versus pre-op: 329 [189-599] pg/mL. P-VEGF; day 1: 55 [46-104] pg/mL and day 10: 58 [20-154] pg/mL versus pre-op: 23 [13-46] pg/mL), falling towards preoperative levels by six weeks. Platelet count correlated with S-VEGF (rho=0.281; p
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080201700207