Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccines

The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared.Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12 and 24, and the anti-HAV total IgG antibody and IgG subclass pr...

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Bibliographic Details
Published in:Vaccine 2004-05, Vol.22 (15), p.1941-1945
Main Authors: Wang, Xuan-Yi, Xu, Zhiyi, Yao, Xing, Tian, Meiying, Zhou, Liangdi, He, Lifang, Wen, Yumei
Format: Article
Language:English
Subjects:
Applied microbiology
Attenuated
Biological and medical sciences
Child
Child, Preschool
Enzymes
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis A Antibodies - analysis
Hepatitis A Antibodies - biosynthesis
Hepatitis A vaccine
Hepatitis A Vaccines - immunology
Hepatitis A virus
Human viral diseases
Humans
IgG subclass
IgG subclass response to HAV vaccine
Immune system
Immunogenicity
Immunoglobulin G - biosynthesis
Immunoglobulin G - genetics
Inactivated
Infectious diseases
Laboratories
Licenses
Male
Medical sciences
Microbiology
Running headline
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - immunology
Vaccines, Inactivated - immunology
Viral diseases
Viral hepatitis
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Summary:The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared.Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12 and 24, and the anti-HAV total IgG antibody and IgG subclass profile were assessed. In both vaccinated groups, the geometric mean titer (GMT) of anti-HAV peaked 7 months after the initial dose and declined during the following months. The IgG subclass profiles in both vaccinated groups were highly restricted to IgG1 and IgG3. Both vaccines have been shown highly effective in preventing viral hepatitis A in former studies.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2003.11.007