Elevated Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-2 in Malignant Pleural Effusion

• Published in: Acta oncologica 2002, Vol.41 (2), p.182-187
• Main Authors: Olchovsky, David, Shimon, Ilan, Goldberg, Iris, Shulimzon, Tiberiu, Lubetsky, Aharon, Yellin, Alon, Pariente, Clara, Karasik, Avraham, Kanety, Hannah
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Blotting, Western; Breast Neoplasms - etiology; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Breast Neoplasms - secondary; Carcinoma, Non-Small-Cell Lung - etiology; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Female; Host-tumor relations. Immunology. Biological markers; Humans; Immunoenzyme Techniques; Insulin-Like Growth Factor Binding Protein 2 - metabolism; Insulin-Like Growth Factor I - metabolism; Lung Neoplasms - etiology; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lymphoma - etiology; Lymphoma - metabolism; Lymphoma - pathology; Male; Medical sciences; Middle Aged; Pleural Effusion - metabolism; Pneumology; Radioimmunoassay; Respiratory system : syndromes and miscellaneous diseases; Tumors; Up-Regulation
• ISSN: 0284-186X; 1651-226X
• DOI: 10.1080/028418602753669571

Insulin-like growth factor-1 (IGF-1) and its binding proteins (IGFBPs) are produced by many tissues and are present in serum and other biological fluids. Alterations in sera of IGF-1 and 2 and IGFBPs were demonstrated in patients with malignancy, infection and other diseases causing pleural effusion. In this study the IGF-1 and IGFBP-2 content and the specific electrophoretic patterns of IGFBPs in samples of sera and pleural effusions of 25 patients with malignancy, infection and congestive heart failure were investigated. IGF-1 levels in exudative effusions of malignant solid tumors were significantly higher [(mean &#45 SD), 20.9 &#45 7.5 nmol/L, n=9] than in lymphoma (11.0 &#45 5.2 nmol/L, n=5; p