Enhancement of embryo developmental potential by a single administration of GnRH agonist at the time of implantation

• Published in: Human reproduction (Oxford) 2004-05, Vol.19 (5), p.1176-1180
• Main Authors: Tesarik, Jan, Hazout, André, Mendoza, Carmen
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Birth Rate; embryo developmental potential/GnRH agonist/implantation/oocyte donation; Embryo Implantation; Embryology: invertebrates and vertebrates. Teratology; Female; Fundamental and applied biological sciences. Psychology; Gonadotropin-Releasing Hormone - agonists; Humans; Luteolytic Agents - administration & dosage; Oocytes - cytology; Pregnancy; Pregnancy, Multiple; Prospective Studies; Reproductive Techniques, Assisted; Triptorelin Pamoate - administration & dosage
• ISSN: 0268-1161; 1460-2350; 1460-2350
• DOI: 10.1093/humrep/deh235

BACKGROUND: Several reports have shown that inadvertent administration of a GnRH agonist in the luteal phase does not compromise pregnancy. Moreover, some studies suggested that, unexpectedly, the embryo developmental potential is improved in these conditions. This prospective controlled study was designed to test this hypothesis. METHODS: In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time. RESULTS: Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group. CONCLUSIONS: GnRH agonist administration at the time of implantation enhances embryo developmental potential, probably by a direct effect on the embryo.