Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model

Background and Objectives It is possible to arterially embolize or directly inject liver tumors in small animal models with ferromagnetic particles that generate hysteretic heating on exposure to an alternating magnetic field. The objective of this study was to compare the response of liver tumors t...

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Bibliographic Details
Published in:Journal of surgical oncology 2002-07, Vol.80 (3), p.149-156
Main Authors: Moroz, Paul, Jones, Stephen K., Gray, Bruce N.
Format: Article
Language:English
Subjects:
Animals
Arterial embolization
Biological and medical sciences
direct injection
Disease Models, Animal
Embolization, Therapeutic
ferromagnetic
Gastroenterology. Liver. Pancreas. Abdomen
Hepatic Artery
hyperthermia
Hyperthermia, Induced - methods
hysteresis
Induced hyperthermia. Cryotherapy
Injections, Intralesional
Liver Neoplasms, Experimental - therapy
liver tumors
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
microsphere
Rabbits
Treatment with physical agents
Treatment. General aspects
Tumors
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Summary:Background and Objectives It is possible to arterially embolize or directly inject liver tumors in small animal models with ferromagnetic particles that generate hysteretic heating on exposure to an alternating magnetic field. The objective of this study was to compare the response of liver tumors to arterial embolization hyperthermia (AEH) and direct injection hyperthermia (DIH). Methods Ten rabbits containing experimental hepatic tumors were treated with AEH, and a second group of ten rabbits were treated with DIH. The tumors of both groups were heated to 43° to 50°C for 20 minutes. Tumor response, which was determined by measuring change in tumor volume and by comparison of tumor mass after treatment with the mass of untreated control tumors of the same age, was assessed 14 days after treatment. Results All tumors treated with AEH decreased in volume by 50% to 94% (P = 0.005), and their average mass (median 1.73 gm) was significantly less than that of untreated control tumors (median 8.01 gm, n = 20; P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.10118