Comparative mapping of human Chromosome 19 with the chicken shows conserved synteny and gives an insight into chromosomal evolution

Human Chromosome 19 (HSA19) is virtually completely sequenced. A complete physical contig map made up of BACs and cosmids is also available for this chromosome. It is, therefore, a rich source of information that we have used as the basis for a comparative mapping study with the chicken. Various ort...

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Bibliographic Details
Published in:Mammalian genome 2002-06, Vol.13 (6), p.310-315
Main Authors: Smith, Jacqueline, Paton, Ian R, Murray, Frazer, Crooijmans, Richard P.M.A, Groenen, Martien A.M, Burt, David W
Format: Article
Language:English
Subjects:
Animals
bacterial artificial chromosomes
chickens
Chickens - genetics
Chromosome Mapping
Chromosomes
Chromosomes, Artificial, Bacterial
Chromosomes, Human, Pair 19
DNA, Complementary
evolution
Evolution, Molecular
genes
genotype
Humans
information sources
karyotyping
mice
Synteny
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Description
Summary:Human Chromosome 19 (HSA19) is virtually completely sequenced. A complete physical contig map made up of BACs and cosmids is also available for this chromosome. It is, therefore, a rich source of information that we have used as the basis for a comparative mapping study with the chicken. Various orthologs of genes known to map to HSA19 have been mapped in the chicken. Five chicken microchromosomes (two of which were previously undefined) are seen to show conserved synteny with this chromosome, along with individual gene homologs on Chr 1 and another tiny microchromosome. Compared with the mouse, which has 12 chromosomal regions homologous to HSA19, the chicken genotype displays fewer evolutionary rearrangements. The ancestral nature of the chicken karyotype is demonstrated and may prove to be an excellent tool for studying genome evolution.
ISSN:0938-8990
1432-1777
DOI:10.1007/s00335-001-3071-1