Electrophysiological findings in X-linked myopathy with excessive autophagy

We report electrophysiological features and magnetic resonance imaging muscle findings in 4 patients and 1 female carrier of X‐linked myopathy with excessive autophagy. Motor units were polyphasic with high mean amplitude and normal duration. The thigh muscles were most severely involved, but myoton...

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Bibliographic Details
Published in:Annals of neurology 2002-05, Vol.51 (5), p.648-652
Main Authors: Jääskeläinen, Satu K., Juel, Vern C., Udd, Bjarne, Villanova, Marcello, Liguori, Rocco, Minassian, Berge A., Falck, Björn, Niemi, Pekka, Kalimo, Hannu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autophagy - genetics
Biological and medical sciences
Diseases of striated muscles. Neuromuscular diseases
Electromyography
Electrophysiology
Female
Genetic Linkage - genetics
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Muscular Diseases - genetics
Muscular Diseases - pathology
Muscular Diseases - physiopathology
Neurology
Vacuoles - genetics
Vacuoles - pathology
X Chromosome
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Summary:We report electrophysiological features and magnetic resonance imaging muscle findings in 4 patients and 1 female carrier of X‐linked myopathy with excessive autophagy. Motor units were polyphasic with high mean amplitude and normal duration. The thigh muscles were most severely involved, but myotonic discharges were abundant in both clinically affected and unaffected muscles. Along with the clinicopathological features, these electrophysiological findings distinguish X‐linked myopathy with excessive autophagy from other limb‐girdle myopathies.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.10173