GSTP1, GSTM1, and GSTT1 genetic polymorphisms in patients with cryptogenic liver cirrhosis

We investigated glutathione S–transferase (GST) P1 Ile (105) Val, T1, and M1 polymorphisms in 45 patients with documented cryptogenic cirrhosis and 56 healthy control subjects. Polymerase chain reaction–based procedures were performed in the studied populations to confirm the genotypes of GSTT1, M1,...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2004-05, Vol.8 (4), p.423-427
Main Authors: Ghobadloo, Shahrokh Mohammadzadeh, Yaghmaei, Bahram, Bakayev, Valery, Goudarzi, Hossein, Noorinayer, Babak, Rad, Farhad Haghighi, Samiy, Saeed, Aghabozorghi, Sohrab, Zali, Mohammad Reza
Format: Article
Language:English
Subjects:
Acyltransferases - genetics
Adult
Aged
Confidence intervals
cryptogenic cirrhosis
Female
Glutathione S–transferase genotype
Glutathione Transferase - genetics
Humans
Liver cirrhosis
Liver Cirrhosis - genetics
Male
Middle Aged
Polymorphism, Genetic
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Summary:We investigated glutathione S–transferase (GST) P1 Ile (105) Val, T1, and M1 polymorphisms in 45 patients with documented cryptogenic cirrhosis and 56 healthy control subjects. Polymerase chain reaction–based procedures were performed in the studied populations to confirm the genotypes of GSTT1, M1, and P1. Ile/Val and Val/Val GSTP1 genotypes were more frequent in the patients with cirrhosis (n = 39, 87%) than in the control subjects (n = 10; 18%) (odds ratio [OR] 34.04; 95% confidence interval [CI] 10.70 to 108.31, P
ISSN:1091-255X
1873-4626
DOI:10.1016/j.gassur.2004.02.005