Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activation

Neurogenesis and apoptosis in the hippocampal dentate gyrus (DG) occur during development and adulthood. However, little is known about how these two processes relate to each other during aging. In this study, we examined apoptosis, proliferation, migration, and survival of newborn cells in the youn...

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Bibliographic Details
Published in:Neurobiology of aging 2004-03, Vol.25 (3), p.361-375
Main Authors: Heine, Vivi M, Maslam, Suharti, Joëls, Marian, Lucassen, Paul J
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Apoptosis
Apoptosis - physiology
Biological and medical sciences
Biomarkers
Cell Count
Cell Differentiation - physiology
Cell Division - physiology
Cell Movement - physiology
Cell Survival - physiology
Corticosterone
Corticosterone - metabolism
Dentate Gyrus - cytology
Dentate Gyrus - growth & development
Dentate Gyrus - physiology
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Hippocampus
Hypothalamo-Hypophyseal System - metabolism
Hypothalamo-Hypophyseal System - secretion
Male
Migration
Nerve Tissue Proteins - metabolism
Neurogenesis
Neuroglia - cytology
Neuroglia - physiology
Neurons - cytology
Neurons - physiology
Phenotype
Pituitary-Adrenal System - metabolism
Pituitary-Adrenal System - secretion
Rat
Rats
Rats, Wistar
Stem Cells - cytology
Stem Cells - physiology
Stress
Stress, Physiological - metabolism
Vertebrates: nervous system and sense organs
Wistar
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Summary:Neurogenesis and apoptosis in the hippocampal dentate gyrus (DG) occur during development and adulthood. However, little is known about how these two processes relate to each other during aging. In this study, we examined apoptosis, proliferation, migration, and survival of newborn cells in the young (2 weeks), young-adult (6 weeks), middle-aged (12 months), and old (24 months) rat DG. We also measured dentate volume and cell numbers, along with basal corticosterone and stress response parameters. We show that new cell proliferation and apoptosis slow down profoundly over this time period. Moreover, migration and differentiation into a neuronal or glial phenotype was strongly reduced from 6 weeks of age onwards; it was hardly present in middle-aged and old rats as confirmed by confocal analysis. Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group.
ISSN:0197-4580
1558-1497
DOI:10.1016/S0197-4580(03)00090-3