Measurement of density variations in tablets using X-ray computed tomography

In this paper the application of X-ray computed tomography (CT) to measure the material density distribution in pharmaceutical tablets is discussed. X-ray CT is a non-destructive inspection technique which provides cross-sectional images in different planes through a component. The CT image values p...

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Bibliographic Details
Published in:International journal of pharmaceutics 2004-03, Vol.271 (1), p.215-224
Main Authors: Sinka, I.C., Burch, S.F., Tweed, J.H., Cunningham, J.C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellulose - chemistry
Density distribution
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Tablet
Tablets - chemistry
Tomography, X-Ray Computed
X-ray computed tomography
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Summary:In this paper the application of X-ray computed tomography (CT) to measure the material density distribution in pharmaceutical tablets is discussed. X-ray CT is a non-destructive inspection technique which provides cross-sectional images in different planes through a component. The CT image values provide information on the local X-ray attenuation coefficients. For a particular material and X-ray energy, X-ray attenuation is approximately proportional to material density. Determination of quantitative density distributions requires consideration of non-linear instrumental effects including scatter and “beam hardening”. Density maps in tablets manufactured under controlled conditions are presented. The results are discussed with reference to the local properties of the material within the tablet and the tablet design features.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2003.11.022