T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis

Objective: To use both whole-brain and normal-appearing brain tissue (NABT) T1 relaxation time histograms to investigate abnormalities in early relapsing-remitting (RR) multiple sclerosis (MS). Background: In patients with established MS, both lesions and NABT exhibit an increase in T1 relaxation ti...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis 2002-05, Vol.8 (3), p.211-216
Main Authors: Griffin, C M, Dehmeshki, J, Chard, D T, Parker, G JM, Barker, G J, Thompson, A J, Miller, D H
Format: Article
Language:English
Subjects:
Adult
Brain - pathology
Echo-Planar Imaging
Female
Gadolinium
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To use both whole-brain and normal-appearing brain tissue (NABT) T1 relaxation time histograms to investigate abnormalities in early relapsing-remitting (RR) multiple sclerosis (MS). Background: In patients with established MS, both lesions and NABT exhibit an increase in T1 relaxation time. By using T1 histogram analysis, it is hoped that such changes in early disease can be detected. Method: Twenty-seven patients and 14 age- and sex-matched controls underwent magnetic resonance imaging (MRI) of the brain, which included the following sequences: 1) proton density (PD)- and T2-weighted fast spin echo (FSE) to measure T2 lesion load, 2) PD- and T1-weighted gradient echos from which T1 relaxation was calculated, and 3) T1-weighted SE imaging pre- and post-triple dose (0.3 mmol/kg) gadolinium (Gd-DTPA) to measure T1 hypointense and gadolinium-enhancing lesion loads, respectively. All patients had RR MS with disease duration
ISSN:1352-4585
1477-0970
DOI:10.1191/1352458502ms807oa