Short‐term resolution of psoriasis after total thyroidectomy for euthyroid multinodular goitre

SUMMARY A 36‐year‐old Chinese female with an 8‐year history of chronic, generalized plaque psoriasis demonstrated a marked improvement of the disease after removal of an intercurrent euthyroid multinodular goitre. Thyroxine was commenced immediately postoperatively. No thyroid antibodies were detect...

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Bibliographic Details
Published in:Australasian journal of dermatology 2002-08, Vol.43 (3), p.214-217
Main Authors: Kuchel, Johanna, Barakate, Michael, Delbridge, Leigh, Agarwal, Gaurav, Beattie, John, Barnetson, Ross
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
chronic plaque psoriasis
Dermatology
epidermal hyperproliferation
Female
Follow-Up Studies
Goiter - complications
Goiter - diagnosis
Goiter - surgery
Humans
Medical sciences
Postoperative Period
Psoriasis - complications
Psoriasis - diagnosis
Psoriasis - radiotherapy
Psoriasis. Parapsoriasis. Lichen
Severity of Illness Index
thyroid
Thyroid Function Tests
Thyroidectomy - methods
Time Factors
Treatment Outcome
Tropical medicine
Ultraviolet Therapy - methods
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Summary:SUMMARY A 36‐year‐old Chinese female with an 8‐year history of chronic, generalized plaque psoriasis demonstrated a marked improvement of the disease after removal of an intercurrent euthyroid multinodular goitre. Thyroxine was commenced immediately postoperatively. No thyroid antibodies were detected and thyroid function and calcium levels remained within normal limits both pre‐ and postoperatively. Four weeks following surgery, narrow‐band ultraviolet B (nbUVB) therapy was recommenced for recurrent psoriasis. The manifestations of psoriasis at this stage were less severe than before thyroidectomy and responded well to treatment, whereas before surgery the response to therapy had been poor. One year following total thyroidectomy, the patient received very effective psoriasis control with nbUVB therapy. The possible role of surgery and thyroid hormones in altering the pathogenesis of psoriasis in the acute setting is clearly of interest and warrants further research consideration.
ISSN:0004-8380
1440-0960
DOI:10.1046/j.1440-0960.2002.00599.x