Multi-subunit acetyl-CoA carboxylases

Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dis...

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Bibliographic Details
Published in:Progress in Lipid Research 2002-09, Vol.41 (5), p.407-435
Main Authors: Cronan, John E, Waldrop, Grover L
Format: Article
Language:English
Subjects:
Acetyl-CoA Carboxylase - chemistry
Acetyl-CoA Carboxylase - genetics
Acetyl-CoA Carboxylase - physiology
Carrier Proteins - chemistry
Catalysis
Escherichia coli - enzymology
Fatty Acid Synthase, Type II
Humans
Mutation
Plants - enzymology
Structure-Activity Relationship
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Summary:Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.
ISSN:0163-7827
1873-2194
DOI:10.1016/S0163-7827(02)00007-3