Vertical transmission of Neospora caninum in BALB/c mice in both acute and chronic infection

To examine the frequency of congenital infection by Neospora caninum, BALB/c mice were inoculated intraperitoneally with tachyzoites of N. caninum either during pregnancy (Group 1) or 4 weeks or more before pregnancy (Group 2). Further, the mice inoculated during pregnancy were bred at 4 weeks or mo...

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Bibliographic Details
Published in:Veterinary parasitology 2004-05, Vol.121 (3), p.323-328
Main Authors: Omata, Y, Nidaira, M, Kano, R, Kobayashi, Y, Koyama, T, Furuoka, H, Maeda, R, Matsui, T, Saito, A
Format: Article
Language:English
Subjects:
acute course
acute infection
Animals
Animals, Newborn
BALB/c mice
Brain - parasitology
chronic diseases
Coccidiosis - congenital
Coccidiosis - transmission
congenital infection
Congenital transmission
disease incidence
Female
infection
Infectious Disease Transmission, Vertical
Litter Size
Lymph Nodes - parasitology
Male
Mice
Mice, Inbred BALB C
neonates
Neospora - growth & development
Neospora caninum
neosporosis
Pregnancy
Pregnancy Complications, Parasitic - parasitology
Spleen - parasitology
strains
transmission rates
transplacental transmission
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Summary:To examine the frequency of congenital infection by Neospora caninum, BALB/c mice were inoculated intraperitoneally with tachyzoites of N. caninum either during pregnancy (Group 1) or 4 weeks or more before pregnancy (Group 2). Further, the mice inoculated during pregnancy were bred at 4 weeks or more after delivery to form Group 3. Congenital transmission was observed in 76% of the neonates of the mice in Group 1 and in 50% of the neonates of the mice in Group 2. Interestingly, congenital transmission was observed in 86% of the neonates from Group 3. These results suggest that chronically-infected BALB/c mice efficiently transmit N. caninum infection to their offspring.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2004.03.003