The ideal inhaler: design and characteristics to improve outcomes

Inhalation therapy is likely to continue to dominate asthma treatment. The pressurised metered dose inhaler (pMDI) accounts for most of the inhaler market world-wide, but is inefficient and difficult to use. Dry powder inhalers (DPIs) have several advantages over MDIs. They are breath-activated, eas...

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Bibliographic Details
Published in:Respiratory medicine 2004-04, Vol.98, p.S10-S16
Main Author: O’Connor, Brian J
Format: Article
Language:English
Subjects:
Anti-Asthmatic Agents - administration & dosage
Asthma - drug therapy
Biological and medical sciences
Equipment Design
Humans
Ideal inhaler
Inhalation
Medical sciences
Metered Dose Inhalers
Novolizer
Pneumology
Turbuhaler
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Summary:Inhalation therapy is likely to continue to dominate asthma treatment. The pressurised metered dose inhaler (pMDI) accounts for most of the inhaler market world-wide, but is inefficient and difficult to use. Dry powder inhalers (DPIs) have several advantages over MDIs. They are breath-activated, easy and convenient to use and environmentally friendly. The Turbuhaler ® is the most widely used DPI, offering good deposition with sufficient inspiratory flow, but it provides no confirmation of dosing, exhibits high dose variation, has a high intrinsic resistance, and inspiratory flow profile-dependent drug deposition. The Novolizer ® (VIATRIS, Frankfurt, Germany) is a new DPI which has several characteristics of an ‘ideal’ inhaler. It is convenient and easy to use, demonstrate and teach, provides accurate and consistent drug delivery and provides patients with feedback of dose taken. The Novolizer ® is a promising new delivery system for inhalation therapy.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2004.02.006