Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients

Neurotrophic factors regulate neuronal development as well as synaptic plasticity, and their impairment is often implicated as a cause of schizophrenia. Among various neurotrophic molecules, brain-derived neurotrophic factor (BDNF) levels have been found to be increased in the corticolimbic regions...

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Bibliographic Details
Published in:Psychiatry research 2002-07, Vol.110 (3), p.249-257
Main Authors: Toyooka, Kazuhiko, Asama, Koue, Watanabe, Yuichiro, Muratake, Tatsuyuki, Takahashi, Makoto, Someya, Toshiyuki, Nawa, Hiroyuki
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Animals
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
BDNF
Biological and medical sciences
Blood Platelets - metabolism
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - metabolism
Chronic Disease
Female
Haloperidol
Haloperidol - pharmacology
Haloperidol - therapeutic use
Humans
Male
Medical sciences
Neurotrophin
Platelet
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Rats
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - metabolism
Vesicle
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Summary:Neurotrophic factors regulate neuronal development as well as synaptic plasticity, and their impairment is often implicated as a cause of schizophrenia. Among various neurotrophic molecules, brain-derived neurotrophic factor (BDNF) levels have been found to be increased in the corticolimbic regions of patients’ brains. In the present study, we assessed peripheral BDNF levels in whole blood as well as in the serum of two independent groups of schizophrenic patients ( n=34 in each group) and healthy volunteers ( n=35 and n=27, respectively). BDNF protein levels in fresh serum and blood of the patients and volunteers were measured using a two-site enzyme immunoassay and correlated with the number and decay of platelets. In addition to the studies of patients and volunteers, neuroleptic effects on BDNF levels were assessed by administering haloperidol to adult rats for 2 weeks or 5 months. The major findings were as follows: BDNF levels were significantly reduced in the serum of schizophrenic patients ( P
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(02)00127-0