Relative value of N-terminal probrain natriuretic peptide, TIMI risk score, ACC/AHA prognostic classification and other risk markers in patients with non-ST-elevation acute coronary syndromes

• Published in: European heart journal 2004-05, Vol.25 (10), p.859-866
• Main Authors: Bazzino, Oscar, Fuselli, Juan J, Botto, Fernando, Perez de Arenaza, Diego, Bahit, Cecilia, Dadone, Jorge
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Aged; Angina, Unstable - blood; Biological and medical sciences; Biomarkers - blood; Cardiac markers; Cardiology. Vascular system; Coronary heart disease; Female; Heart; Hospitalization; Humans; Male; Medical sciences; Myocardial Infarction - blood; N-terminal probrain natriuretic peptide; Natriuretic Peptide, Brain - metabolism; Prognosis; Prospective Studies; Regression Analysis; Risk Factors; Risk stratification; Time Factors
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1016/j.ehj.2004.03.004

Aims We prospectively studied the additive value of N-terminal probrain natriuretic peptide (NT-proBNP) in relation to the Thrombolysis in Myocardial Infarction (TIMI) risk score and the American College of Cardiology/American Heart Association (ACC/AHA) joint prognostic classification, and compared the predictive capacity of NT-proBNP, troponin T (TnT), C-reactive protein (hsCRP), myoglobin, and creatine kinase-MB (CK-MB) concentrations in a cohort of 1483 consecutive patients with non-ST-segment-elevation acute coronary syndromes (NSTE-ACS). Methods and results Centralised measurements of NT-proBNP, TnT, myoglobin, and hsCRP were performed 3 h (median) after admission. Adjusting by clinical, ECG variables, and biomarkers, NT-proBNP concentration was the strongest independent predictor of in-hospital (OR 1.7, 95% CI: 1.31–2.20, \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(p{