False positive uptake of metaiodobenzylguanidine in hepatocellular carcinoma

We present the case of a patient who showed increased accumulation of (123)I-metaiodobenzylguanidine (MIBG) in hepatocellular carcinoma, leading to a false presumptive diagnosis of intrahepatic neuroendocrine tumour. The increase in uptake was not seen on images obtained 4 h after tracer injection b...

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Bibliographic Details
Published in:British journal of radiology 2002-06, Vol.75 (894), p.548-551
Main Authors: INOUE, Y, AKAHANE, M, KITAZAWA, T, IJICHI, H, OBI, S, YOSHIKAWA, K, OHTOMO, K, OMATA, M
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - pharmacokinetics
Aged
Biological and medical sciences
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - metabolism
Diagnosis, Differential
Digestive system
False Positive Reactions
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hypertension - diagnostic imaging
Investigative techniques, diagnostic techniques (general aspects)
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - metabolism
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Neuroendocrine Tumors - diagnostic imaging
Neuroendocrine Tumors - metabolism
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radionuclide Imaging
Radiopharmaceuticals - pharmacokinetics
Tumors
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Summary:We present the case of a patient who showed increased accumulation of (123)I-metaiodobenzylguanidine (MIBG) in hepatocellular carcinoma, leading to a false presumptive diagnosis of intrahepatic neuroendocrine tumour. The increase in uptake was not seen on images obtained 4 h after tracer injection but was evident on those taken after 24 h, suggesting slower washout from the liver tumour than from non-tumoural liver parenchyma. Our observations indicate that a non-neuroendocrine malignant tumour may exhibit high accumulation of MIBG associated with prolonged retention.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr.75.894.750548