Aldosterone and cardiovascular remodelling: focus on myocardial failure

Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study...

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Bibliographic Details
Published in:Journal of the renin-angiotensin-aldosterone system 2004-03, Vol.5 (1), p.3-13
Main Authors: Shieh, Frederick K, Kotlyar, Eugene, Sam, Flora
Format: Article
Language:English
Subjects:
Aldosterone - metabolism
Animals
Blood Vessels - physiopathology
Cardiac Output, Low - genetics
Cardiac Output, Low - metabolism
Cardiac Output, Low - physiopathology
Cardiovascular System - physiopathology
Cytochrome P-450 CYP11B2 - genetics
Humans
Oxidative Stress
Polymorphism, Genetic
Ventricular Remodeling
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Summary:Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.
ISSN:1470-3203
1752-8976
DOI:10.3317/jraas.2004.005