Strong impact of highly active antiretroviral therapy on survival in patients with human immunodeficiency virus‐associated Hodgkin's disease

Summary Hodgkin's disease (HD) is the most common non‐acquired immunodeficiency syndrome (AIDS)‐defining malignancy in human immunodeficiency virus (HIV)‐infected patients. We analysed the outcome of patients with HIV‐associated HD (HIV‐HD) with respect to the use and efficacy of highly active...

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Bibliographic Details
Published in:British journal of haematology 2004-05, Vol.125 (4), p.455-462
Main Authors: Hoffmann, Christian, Chow, Kai Uwe, Wolf, Eva, Faetkenheuer, Gerd, Stellbrink, Hans‐Juergen, Lunzen, Jan, Jaeger, Hans, Stoehr, Albrecht, Plettenberg, Andreas, Wasmuth, Jan‐Christian, Rockstroh, Juergen, Mosthaf, Franz, Horst, Heinz‐August, Brodt, Hans‐Reinhard
Format: Article
Language:English
Subjects:
acquired immunodeficiency syndrome
Adult
Age Factors
Anti-HIV Agents - therapeutic use
antiretroviral therapy
Antiretroviral Therapy, Highly Active
Biological and medical sciences
CD4 Lymphocyte Count
Female
Hematologic and hematopoietic diseases
Hematology
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - mortality
HIV-1
Hodgkin Disease - drug therapy
Hodgkin Disease - mortality
Hodgkin Disease - virology
Hodgkin's disease
human immunodeficiency virus
Human viral diseases
Humans
immune recovery
Infectious diseases
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Prospective Studies
Regression Analysis
Remission Induction
Survival Rate
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
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Summary:Summary Hodgkin's disease (HD) is the most common non‐acquired immunodeficiency syndrome (AIDS)‐defining malignancy in human immunodeficiency virus (HIV)‐infected patients. We analysed the outcome of patients with HIV‐associated HD (HIV‐HD) with respect to the use and efficacy of highly active antiretroviral therapy (HAART) and other prognostic factors. To evaluate the effects of several variables on overall survival (OS), Kaplan–Meier statistics and extended Cox regression analysis were performed. Response to HAART was used as a time‐dependent variable and was defined as an increase of >0·1 × 109 CD4 cells/l and/or at least one viral load
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2004.04934.x