Comparison of whole-body FDG-PET to bone scan for detection of bone metastases in patients with a new diagnosis of lung cancer

The purpose of this study was to compare the accuracy and agreement of whole-body positron-emission tomography (PET) scan to bone scintigraphy for the detection of bony metastases in staging patients with newly diagnosed lung cancer. The tumor registry and nuclear medicine database at our institutio...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2004-06, Vol.44 (3), p.317-325
Main Authors: Cheran, Sendhil Kumar, Herndon, James E, Patz, Edward F
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Bone scintigraphy
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - secondary
Carcinoma, Small Cell - diagnostic imaging
Carcinoma, Small Cell - secondary
Female
Fluorodeoxyglucose F18
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Neoplasm Staging
Osseous metastasis
Pneumology
Positron emission tomography
Radionuclide Imaging - methods
Radiopharmaceuticals
Reproducibility of Results
Retrospective Studies
Tomography, Emission-Computed - methods
Tumors of the respiratory system and mediastinum
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Summary:The purpose of this study was to compare the accuracy and agreement of whole-body positron-emission tomography (PET) scan to bone scintigraphy for the detection of bony metastases in staging patients with newly diagnosed lung cancer. The tumor registry and nuclear medicine database at our institution were queried and identified all patients between July 1998 and August 2002 with a new diagnosis of lung cancer, a whole-body 2-deoxy-2-[ 18 F ]fluoro- d-glucose (FDG)-PET scan, and a bone scan prior to therapy. All of these patients’ radiologic reports were then retrospectively reviewed, and confirmation of bone metastases was determined by consideration of all available clinical information. The sensitivity, specificity, and accuracy for each study were then calculated. Two hundred and fifty-seven patients fulfilled the entrance criteria. One hundred and four patients (40%) presented with stage IV disease, and bone metastases were confirmed in 57 (22%) patients. The accuracies of PET and bone scan were 94 and 85% ( P
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2003.11.008