Synthesis of Substituted Naphthalenes by the Palladium-Catalyzed Annulation of Internal Alkynes

A variety of substituted naphthalenes have been prepared by the palladium-catalyzed carboannulation of internal alkynes. This method (1) forms two new carbon−carbon bonds in a single step, (2) accommodates a variety of functional groups, and (3) affords excellent yields of highly substituted naphtha...

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Bibliographic Details
Published in:Organic letters 2002-07, Vol.4 (15), p.2505-2508
Main Authors: Huang, Qinhua, Larock, Richard C
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Catalysis
Chemistry, Pharmaceutical - methods
Cyclization
Naphthalenes - chemical synthesis
Naphthalenes - chemistry
Palladium - chemistry
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Summary:A variety of substituted naphthalenes have been prepared by the palladium-catalyzed carboannulation of internal alkynes. This method (1) forms two new carbon−carbon bonds in a single step, (2) accommodates a variety of functional groups, and (3) affords excellent yields of highly substituted naphthalenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026128y