Prognostic value of the expression of Ki‐67, CD44 and vascular endothelial growth factor, and microvessel invasion, in renal cell carcinoma

• Published in: BJU international 2004-05, Vol.93 (7), p.1087-1093
• Main Authors: Yildiz, E., Gokce, G., Kilicarslan, H., Ayan, S., Goze, O.F., Gultekin, E.Y.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Renal Cell - blood supply; Carcinoma, Renal Cell - metabolism; CD44; Female; Humans; Hyaluronan Receptors - metabolism; Immunohistochemistry; Ki-67 Antigen - metabolism; Kidney Neoplasms - blood supply; Kidney Neoplasms - metabolism; Kidneys; Ki‐67; Male; Medical sciences; Microcirculation; microvessel invasion; Middle Aged; Neoplasm Proteins - metabolism; Nephrology. Urinary tract diseases; Prognosis; renal cell carcinoma; Survival Analysis; Tumors of the urinary system; Vascular Endothelial Growth Factors - metabolism; VEGF
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1111/j.1464-410X.2004.04786.x

OBJECTIVE To determine if use of cell proliferation, cell adhesion, level of angiogenesis‐related factors and presence of microscopic vascular invasion (MVI) could better predict the biological behaviour of renal cell carcinoma (RCC), which has a widely variable clinical outcome despite the use of conventional prognostic factors (staging and grading). MATERIALS AND METHODS The expression of Ki‐67, CD44H and vascular endothelial growth factor (VEGF) were assessed immunohistochemically in formalin‐fixed, paraffin‐embedded tissues from 48 RCCs, using a Ki‐67 labelling index (LI), CD44 LI and level of VEGF expression, respectively. In addition all the pathological slides were reviewed retrospectively for the presence and absence of MVI. The prognostic value of all the variables assessed was then evaluated, and correlated with the usual prognostic variables and cancer‐specific survival. RESULTS Univariate analysis of cancer‐specific survival showed that tumour stage (P