Capturing the adaptive mutation in yeast

An accurate view of adaptive mutations is essential to evolutionary genetics, but their rarity makes them difficult to study. This can be partially overcome using the many tools of yeast genetics and the ability to study very large populations over many generations. Adaptation to laboratory environm...

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Bibliographic Details
Published in:Research in Microbiology 2004-05, Vol.155 (4), p.217-223
Main Author: Zeyl, Clifford
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Biological - genetics
Biological and medical sciences
Fitness
Fundamental and applied biological sciences. Psychology
Genes, Dominant
Genes, Fungal
Genes, Recessive
Microbiology
Miscellaneous
Mutation
Mycology
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - physiology
Yeast
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Summary:An accurate view of adaptive mutations is essential to evolutionary genetics, but their rarity makes them difficult to study. This can be partially overcome using the many tools of yeast genetics and the ability to study very large populations over many generations. Adaptation to laboratory environments has occurred primarily by chromosomal rearrangements, often involving retrotransposons and apparently selected for their effects on gene regulation. Estimated rates of adaptive mutation are on the order of 1 in 10 11 cell divisions. There remains great potential for the genomic study of variation within yeast species to contribute to our understanding of adaptive mutation.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2003.12.006