Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents

• Published in: Anaesthesia 2004-06, Vol.59 (6), p.584-589
• Main Authors: Struys, M. M. R. F., Bouche, M. P. L. A., Rolly, G., Vandevivere, Y. D. I., Dyzers, D., Goeteyn, W., Versichelen, L. F. M., Van Bocxlaer, J. F. P., Mortier, E. P.
• Format: Article
• Language: English
• Subjects: Absorption; Anaesthetics; Anesthesia; Anesthesia, Closed-Circuit - methods; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Inhalation - chemistry; Biological and medical sciences; Calcium Chloride; Calcium Hydroxide; Carbon dioxide; Carbon Dioxide - chemistry; Carbon monoxide; Carbon Monoxide - chemistry; Compound A; desflurane; Ethers - chemistry; Humans; Hydrocarbons, Fluorinated - chemistry; inhalation; Isoflurane - analogs & derivatives; Isoflurane - chemistry; Medical sciences; Methyl Ethers - chemistry; sevoflurane; Temperature
• ISSN: 0003-2409; 1365-2044
• DOI: 10.1111/j.1365-2044.2004.03704.x

Summary Two new generation carbon dioxide absorbents, DrägerSorb® Free and Amsorb® Plus, were studied in vitro for formation of compound A or carbon monoxide, during minimal gas flow (500 ml.min−1) with sevoflurane or desflurane. Compound A was assessed by gas chromatography/mass spectrometry and carbon monoxide with continuous infrared spectrometry. Fresh and dehydrated absorbents were studied. Mean (SD) time till exhaustion (inspiratory carbon dioxide concentration ≥ 1 kPa) with fresh absorbents was longer with DrägerSorb® Free (1233 (55) min) than with Amsorb® Plus (1025 (55) min; p