Multiple-discriminant analysis for light-scattering spectroscopy and imaging of two-layered tissue phantoms

We propose a new method for enhancing the sensitivity of the reflectance spectrum to the scattering feature of the superficial tissue layer. This method is based on multiple-discriminant analysis in the eigensubspace of the spectrum. Considering the application of scattering imaging, we evaluated th...

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Bibliographic Details
Published in:Optics letters 2004-05, Vol.29 (9), p.971-973
Main Authors: Gono, Kazuhiro, Igarashi, Makoto, Obi, Takashi, Yamaguchi, Masahiro, Ohyama, Nagaaki
Format: Article
Language:English
Subjects:
Discriminant Analysis
Equipment Design
Humans
Light
Models, Theoretical
Phantoms, Imaging
Scattering, Radiation
Sensitivity and Specificity
Spectrum Analysis - instrumentation
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Summary:We propose a new method for enhancing the sensitivity of the reflectance spectrum to the scattering feature of the superficial tissue layer. This method is based on multiple-discriminant analysis in the eigensubspace of the spectrum. Considering the application of scattering imaging, we evaluated this method by performing multispectral imaging of two-layered tissue phantoms. A color map converted from the spectral reflectance corresponds well to variations in the size of the scattering in the first layer.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.29.000971