Accumulation of MDM2 in pleomorphic xanthoastrocytomas

The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53‐mediated cell growth control,...

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Bibliographic Details
Published in:Pathology international 2004-06, Vol.54 (6), p.387-391
Main Authors: Matsumoto, Kenichi, Suzuki, Satoshi O., Fukui, Masashi, Iwaki, Toru
Format: Article
Language:English
Subjects:
Adolescent
Adult
Astrocytoma - genetics
Astrocytoma - metabolism
Astrocytoma - pathology
Biomarkers, Tumor - metabolism
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Child
Child, Preschool
DNA, Neoplasm - analysis
Electrophoresis, Gel, Two-Dimensional
Female
Gene Amplification
Humans
Immunoenzyme Techniques
immunohistochemistry
Male
mdm2
Middle Aged
molecular genetics
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
p53
pleomorphic xanthoastrocytoma
Polymerase Chain Reaction
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53 - metabolism
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Summary:The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53‐mediated cell growth control, were studied in eight specimens of PXA obtained from five patients. All of the PXA samples showed at least focal immunopositivity for MDM2. However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2004.01637.x