Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

Intranasal (IN) administration of IFNβ-1b was examined as a route for targeted delivery to the rat central nervous system (CNS). Intranasal administration resulted in significant delivery throughout the CNS and cervical lymph nodes with low delivery to peripheral organs. At similar blood levels, int...

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Bibliographic Details
Published in:Journal of neuroimmunology 2004-06, Vol.151 (1), p.66-77
Main Authors: Ross, T.M, Martinez, P.M, Renner, J.C, Thorne, R.G, Hanson, L.R, Frey, W.H
Format: Article
Language:English
Subjects:
Administration, Intranasal
Animals
Autoradiography
Blood-Brain Barrier - physiology
Blood–brain barrier
Blotting, Western
Brain Chemistry
Central Nervous System - chemistry
Central Nervous System - metabolism
Cervical Vertebrae
Cytokines
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - metabolism
Injections, Intravenous
Interferon-beta - administration & dosage
Interferon-beta - metabolism
Interferon-β
Intranasal
Lymph Nodes
Male
Multiple sclerosis
Multiple Sclerosis - drug therapy
Rats
Tissue Distribution
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Summary:Intranasal (IN) administration of IFNβ-1b was examined as a route for targeted delivery to the rat central nervous system (CNS). Intranasal administration resulted in significant delivery throughout the CNS and cervical lymph nodes with low delivery to peripheral organs. At similar blood levels, intravenous (IV) administration of IFNβ-1b yielded 88–98% lower CNS levels and 100–1650% greater peripheral organ levels compared to intranasal. Autoradiography confirmed much greater delivery to the CNS with intranasal administration. Intranasally administered IFNβ-1b reached the brain intact and produced tyrosine phosphorylation of IFN receptor in the CNS. Intranasal administration offers a non-invasive method of drug delivery for multiple sclerosis (MS) that bypasses the blood–brain barrier (BBB) and directly targets the CNS and lymph nodes.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2004.02.011