Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

Summary Background Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper‐responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper‐responsiveness and is postulated as...

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Bibliographic Details
Published in:Clinical and experimental allergy 2004-05, Vol.34 (5), p.757-760
Main Authors: Jongepier, H., Boezen, H. M., Dijkstra, A., Howard, T. D., Vonk, J. M., Koppelman, G. H., Zheng, S. L., Meyers, D. A., Bleecker, E. R., Postma, D. S.
Format: Article
Language:English
Subjects:
ADAM Proteins
Adolescent
Adult
Aging - physiology
Allergic diseases
Asthma - genetics
Asthma - physiopathology
Biological and medical sciences
bronchial asthma
Chronic obstructive pulmonary disease, asthma
Disease Progression
FEV1
Forced Expiratory Volume
Genetic Predisposition to Disease
Humans
Immunopathology
Longitudinal Studies
Lung - physiopathology
Medical sciences
Metalloendopeptidases - genetics
Pneumology
Polymorphism, Genetic
Polymorphism, Single Nucleotide
SNP
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Summary:Summary Background Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper‐responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper‐responsiveness and is postulated as a gene for airway remodelling. Objective To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma. Methods In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV1 decline. Results The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV1 (P
ISSN:0954-7894
1365-2222
DOI:10.1111/j.1365-2222.2004.1938.x