Characterization of a novel MICA allele, MICA047

: We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence‐specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with p...

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Bibliographic Details
Published in:Tissue antigens 2002-04, Vol.59 (4), p.308-310
Main Authors: Zhang, Y., Lázaro, A.M., Mirbaha, F., Lavingia, B., Vorhaben, R., Stastny, P.
Format: Article
Language:English
Subjects:
Alleles
Histocompatibility Antigens Class I - genetics
Humans
MICA047
Molecular Sequence Data
Phylogeny
polymorphism
Polymorphism, Genetic
Sequence Homology, Nucleic Acid
sequence-based typing
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Summary:: We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence‐specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with previously defined MICA alleles, revealed that the new allele is similar to MICA*041 except for one nucleotide substitution at position 811 (C→G). It appears that this new allele could have been generated by an interallelic sequence exchange between MICA*011 and MICA*0411.
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2002.590409.x