Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis

Background and aim: Non-alcoholic steatohepatitis (NASH), the association of steatosis with an inflammatory response, is a novel liver disease of unknown pathogenesis and prognosis. Triacylglycerols and their precursors, the fatty acids, are the likely candidates to accumulate in the hepatocyte. Dis...

Full description

Saved in:
Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2002-06, Vol.21 (3), p.219-223
Main Authors: TAVARES DE ALMEIDA, I., CORTEZ-PINTO, H., FIDALGO, G., RODRIGUES, D., CAMILO, M.E.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Case-Control Studies
Disease Progression
fatty acids
Fatty Acids, Nonesterified - blood
fatty liver
Fatty Liver - blood
Fatty Liver - etiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis
Humans
Liver - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
NASH
obesity
Other diseases. Semiology
steatosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and aim: Non-alcoholic steatohepatitis (NASH), the association of steatosis with an inflammatory response, is a novel liver disease of unknown pathogenesis and prognosis. Triacylglycerols and their precursors, the fatty acids, are the likely candidates to accumulate in the hepatocyte. Disturbed fatty acid metabolism can be involved in the pathogenesis of NASH but there is no information concerning its plasma fatty acid profile. The aim of this study was to evaluate plasma total (esterified plus free) and free fatty acids concentrations to assess the association of NASH with plasma fatty acid accumulation. Materials and methods: Overnight fasting blood samples from 22 biopsy-proven NASH patients and of 6 matched age healthy controls were studied. Results: NASH patients had significantly higher concentration of total and free fatty acids than controls (P
ISSN:0261-5614
1532-1983
DOI:10.1054/clnu.2001.0529