Distribution of serotonin 5-hydroxytriptamine 1B (5-HT 1B) receptors in the normal rat hypothalamus

This is the study first attempting to evaluate distribution of neurons expressing serotonin 5-hydroxytriptamine 1B (5-HT 1B) receptors in hypothalamus by using immunocytochemistry. The 5-HT 1B-immunoreactive neurons were widely distributed in hypothalamus. Accumulations of 5-HT 1B neurons occurred i...

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Bibliographic Details
Published in:Neuroscience letters 2002-08, Vol.328 (2), p.155-159
Main Authors: Makarenko, I.G, Meguid, M.M, Ugrumov, M.V
Format: Article
Language:English
Subjects:
5-hydroxytryptamine
Animals
Brain
Double-labeling
Feeding
Hypothalamus - cytology
Hypothalamus - metabolism
Immunohistochemistry
Immunohistohemistry
Magnocellular neurons
Male
Neurons - cytology
Neurons - metabolism
Neuropeptide Y - metabolism
Presynaptic Terminals - metabolism
Presynaptic Terminals - ultrastructure
Rats
Rats, Inbred F344
Receptor, Serotonin, 5-HT1B
Receptors, Serotonin - metabolism
Serotonin - metabolism
Synaptic Transmission - physiology
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Summary:This is the study first attempting to evaluate distribution of neurons expressing serotonin 5-hydroxytriptamine 1B (5-HT 1B) receptors in hypothalamus by using immunocytochemistry. The 5-HT 1B-immunoreactive neurons were widely distributed in hypothalamus. Accumulations of 5-HT 1B neurons occurred in magnocellular nuclei, supraoptic nucleus, paraventricular nucleus (dorsolateral part) and accessory perifornical, circular and retrochiasmatic nuclei. Magnocellular neurons manifested an intense immunostaining suggesting a high level of 5-HT 1B receptors. Large and middle-sized neurons with different 5-HT 1B staining patterns were scattered throughout lateral hypothalamus, periventricular nucleus and lateral preoptic area. Immunofluorescent double-labeling revealed a great overlapping of the distribution 5-HT 1B neurons and dense network of neuropeptide Y-immunoreactive fibers in paraventricular, supraoptic and arcuate nuclei. The potential functional significance of 5-HT 1B receptors in the 5-HT control of endocrine functions and feeding are discussed.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00345-2