In vitro microbicidal activity of W/O/W multiple emulsion for vaginal administration

The microbicidal activity of a W/O/W multiple emulsion destined for vaginal application, containing lactic acid in the internal aqueous phase, octadecylamine (ODA) in the oily phase and benzalkonium chloride (CBZ) in the external aqueous phase was evaluated against three microbial strains: Escherich...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2002-07, Vol.20 (1), p.50-56
Main Authors: Tedajo, G.M, Bouttier, S, Grossiord, J.L, Marty, J.P, Seiller, M, Fourniat, Jacky
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Anti-Infective Agents, Local - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Benzalkonium chloride
Benzalkonium Compounds - pharmacology
Biological and medical sciences
Drug Delivery Systems
Emulsions - administration & dosage
Emulsions - chemistry
Fungi - drug effects
General pharmacology
Hydrogen-Ion Concentration
In Vitro Techniques
Lactic Acid - administration & dosage
Lactic Acid - chemistry
Magnesium Sulfate - administration & dosage
Magnesium Sulfate - chemistry
Medical sciences
Microbial Sensitivity Tests
Microbicidal activity
Miscellaneous. Antibiotics with multiple activities
Octadecylamine
Oils - administration & dosage
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Solubility
W/O/W emulsions
Water
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Summary:The microbicidal activity of a W/O/W multiple emulsion destined for vaginal application, containing lactic acid in the internal aqueous phase, octadecylamine (ODA) in the oily phase and benzalkonium chloride (CBZ) in the external aqueous phase was evaluated against three microbial strains: Escherichia coli, Staphylococcus aureus and Candida albicans. The results were different depending on the procedure used. Interpretable results were obtained if only a gentle agitation was used just after the introduction of the microbial suspension to the product. This suggested that vigorous agitation lead to a variable fraction of CBZ or ODA entrapped in the micelles of ethylene and propylene oxide copolymer (COE).
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(02)00108-5