Long‐term cisapride treatment improves diabetic gastroparesis but not glycaemic control

Background: In patients with diabetic gastroparesis, delayed food delivery to the intestine may become a major obstacle to post‐prandial glycaemic control. Aim: To investigate whether cisapride accelerates gastric emptying in the long term or improves diabetes control in patients with diabetic gastr...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2002-07, Vol.16 (7), p.1341-1346
Main Authors: Braden, B., Enghofer, M., Schaub, M., Usadel, K.‐H., Caspary, W. F., Lembcke, B.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Blood Glucose - metabolism
Breath Tests - methods
Cisapride - therapeutic use
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - physiopathology
Diabetic Neuropathies - blood
Diabetic Neuropathies - drug therapy
Diabetic Neuropathies - physiopathology
Digestive system
Drug Administration Schedule
Dyspepsia - drug therapy
Female
Gastric Emptying - drug effects
Gastrointestinal Agents - therapeutic use
Gastroparesis - drug therapy
Glycated Hemoglobin A - metabolism
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Serotonin Receptor Agonists - therapeutic use
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Summary:Background: In patients with diabetic gastroparesis, delayed food delivery to the intestine may become a major obstacle to post‐prandial glycaemic control. Aim: To investigate whether cisapride accelerates gastric emptying in the long term or improves diabetes control in patients with diabetic gastroparesis. Methods: Eighty‐five patients with long‐standing insulin‐dependent diabetes mellitus (glycosylated haemoglobin (HbA1c) > 7.0%), dyspepsia and diabetic neuropathy were tested for impaired gastric emptying of solids by the 13C‐octanoate breath test. Nineteen of these patients with severe diabetic gastroparesis (i.e. t1/2 > 170 min) were randomly treated with 10 mg cisapride t.d.s. (n=9) or placebo (n=10) for 12 months. Thereafter, the breath test, dyspeptic symptoms and HbA1c values were reassessed. Results: Half emptying times in nine patients with diabetic gastroparesis were significantly shortened by cisapride (175 ± 46 min vs. 227 ± 40 min; P 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.2002.01257.x