Chromosomal imbalances in meningeal solitary fibrous tumors

We present the results of a comparative genomic hybridization (CGH) analysis of three meningeal solitary fibrous tumors (SFT). One case showed loss of chromosome 3 and two tumors had deletions of the region 3p21∼p26. Other chromosomal losses included 4p15, 8q22∼q24, 10, 11q14∼q25, 17q11∼q23, 20, and...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2002-06, Vol.135 (2), p.160-164
Main Authors: Martin, Andrew J, Summersgill, Brenda M, Fisher, Cyril, Shipley, Janet M, Dean, Andrew F
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cerebellar Neoplasms - genetics
Cerebellopontine Angle
Female
Humans
Infratentorial Neoplasms - genetics
Male
Medical sciences
Meningeal Neoplasms - genetics
Meningioma - genetics
Middle Aged
Neurology
Tumors of the nervous system. Phacomatoses
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Summary:We present the results of a comparative genomic hybridization (CGH) analysis of three meningeal solitary fibrous tumors (SFT). One case showed loss of chromosome 3 and two tumors had deletions of the region 3p21∼p26. Other chromosomal losses included 4p15, 8q22∼q24, 10, 11q14∼q25, 17q11∼q23, 20, and 21 in one case each. In addition, there were gains of 18p11∼p13 in one case, and 1p11∼p36 and 20q11∼q13 in another. To our knowledge, there are no previous CGH or cytogenetic data on meningeal SFT, and loss of material on chromosome 3 has not been described in SFT at other sites. Our findings are discussed in relation to published molecular genetic and cytogenetic data on meningioma and hemangiopericytoma, the two lesions with which meningeal SFT are most likely to be confused.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(01)00646-X