A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ

The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented. The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro a...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-06, Vol.14 (12), p.3161-3164
Main Authors: Reynolds, R.C., Srivastava, S., Ross, L.J., Suling, W.J., White, E.L.
Format: Article
Language:English
Subjects:
Anti-bacterial
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - physiology
Biological and medical sciences
Cytoskeletal Proteins - antagonists & inhibitors
Cytoskeletal Proteins - physiology
FtsZ
Medical sciences
Miscellaneous
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - growth & development
Pharmacology. Drug treatments
Pteridines - chemistry
Pteridines - pharmacology
Tuberculosis
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Summary:The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented. The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.04.012