AT1 Angiotensin II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture

Angiotensin II (Ang II) increases intracellular calcium concentration ([Ca 2+] i) in both normal and cancerous human breast cells in primary culture. Maximal [Ca 2+] i increase is obtained using 100 nM Ang II in both cell types; in cancerous breast cells, [Ca 2+] i increase (Δ[Ca 2+] i) is 135±10 nM...

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2002-07, Vol.32 (1), p.1-10
Main Authors: Greco, S, Elia, M.G, Muscella, A, Storelli, C, Marsigliante, S
Format: Article
Language:English
Subjects:
Angiotensin II - pharmacology
Breast Neoplasms
Calcium - metabolism
Calcium Signaling - drug effects
Calcium Signaling - physiology
Epithelial Cells - cytology
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Female
Gene Expression
Humans
Receptor, Angiotensin, Type 1
Receptors, Angiotensin - genetics
Receptors, Angiotensin - metabolism
Tumor Cells, Cultured
Type C Phospholipases - metabolism
Vasoconstrictor Agents - pharmacology
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Summary:Angiotensin II (Ang II) increases intracellular calcium concentration ([Ca 2+] i) in both normal and cancerous human breast cells in primary culture. Maximal [Ca 2+] i increase is obtained using 100 nM Ang II in both cell types; in cancerous breast cells, [Ca 2+] i increase (Δ[Ca 2+] i) is 135±10 nM, while in normal breast cells it reaches 65±5 nM ( P
ISSN:0143-4160
1532-1991
DOI:10.1016/S0143-4160(02)00077-5