Loading…
Chronic fatigue following infection by Coxiella burnetii (Q fever): ten‐year follow‐up of the 1989 UK outbreak cohort
Background: Some patients exposed to Q fever (Coxiella burnetii infection) may develop chronic fatigue. Aim: To determine whether subjects involved in the West Midlands Q fever outbreak of 1989 had increased fatigue, compared to non‐exposed controls, 10 years after exposure. Design: Matched cohort s...
Saved in:
| Published in: | QJM : An International Journal of Medicine 2002-08, Vol.95 (8), p.527-538 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c492t-1f8c62c8a739be1094901624b65790694fdf6815eab51895688f52d3cfe172833 |
|---|---|
| cites | |
| container_end_page | 538 |
| container_issue | 8 |
| container_start_page | 527 |
| container_title | QJM : An International Journal of Medicine |
| container_volume | 95 |
| creator | WILDMAN, M.J. SMITH, E.G. GROVES, J. BEATTIE, J.M. CAUL, E.O. AYRES, J.G. |
| description | Background: Some patients exposed to Q fever (Coxiella burnetii infection) may develop chronic fatigue. Aim: To determine whether subjects involved in the West Midlands Q fever outbreak of 1989 had increased fatigue, compared to non‐exposed controls, 10 years after exposure. Design: Matched cohort study comparing cases to age‐, sex‐ and smoking‐history‐matched controls not exposed to Q fever. Methods: A postal questionnaire was sent to subjects at home, followed by further assessment in hospital, including a physical examination and blood tests. Results: Of 108 Q‐exposed subjects, 70 (64.8%) had fatigue, 37 idiopathic chronic fatigue (ICF) (34.3%), vs. 29/80 (36.3%) and 12 (15.0%), respectively, in controls. In 77 matched pairs, fatigue was commoner in Q‐exposed subjects than in controls: 50 (64.9%) vs. 27 (35.1%), p |
| doi_str_mv | 10.1093/qjmed/95.8.527 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71940992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71940992</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-1f8c62c8a739be1094901624b65790694fdf6815eab51895688f52d3cfe172833</originalsourceid><addsrcrecordid>eNpdkc9uEzEQxleIipbClSOykEBw2NR_1zY3iCgFIiFEKxAXy-vYjdPNOrW90Nz6CH1GngSnWYrEaWY0v_k0n76qeoLgBEFJji6XKzs_kmwiJgzze9UBog2sMZHk_t-eY7ZfPUxpCSGknIoH1T7CiDIi8UG1mS5i6L0BTmd_PljgQteFX74_B7531mQfetBuwDRcedt1GrRD7G32Hrz8Apz9aeOr1yDb_vf1zcbqOJ6XaViD4EBeWICkkODsEwhDbqPVF8CERYj5UbXndJfs47EeVmfH706nJ_Xs8_sP0zez2lCJc42cMA02QnMiW1s8UwlRg2nbMC5hI6mbu0YgZnXLkJCsEcIxPCfGWcSxIOSwerHTXcdwOdiU1cons_XS2zAkxZGkUEpcwGf_gctQzJbfFMaSCUm5KNBkB5kYUorWqXX0Kx03CkG1TUTdJqIkU0KVRMrB01F1aLeLO3yMoADPR0AnozsXdW98-scRQbG89VHvOJ-yvbrb63ihGk44UyfffxTV2bevH0_fKkz-AB0XpFk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229589478</pqid></control><display><type>article</type><title>Chronic fatigue following infection by Coxiella burnetii (Q fever): ten‐year follow‐up of the 1989 UK outbreak cohort</title><source>Oxford Journals Online</source><creator>WILDMAN, M.J. ; SMITH, E.G. ; GROVES, J. ; BEATTIE, J.M. ; CAUL, E.O. ; AYRES, J.G.</creator><creatorcontrib>WILDMAN, M.J. ; SMITH, E.G. ; GROVES, J. ; BEATTIE, J.M. ; CAUL, E.O. ; AYRES, J.G.</creatorcontrib><description>Background: Some patients exposed to Q fever (Coxiella burnetii infection) may develop chronic fatigue. Aim: To determine whether subjects involved in the West Midlands Q fever outbreak of 1989 had increased fatigue, compared to non‐exposed controls, 10 years after exposure. Design: Matched cohort study comparing cases to age‐, sex‐ and smoking‐history‐matched controls not exposed to Q fever. Methods: A postal questionnaire was sent to subjects at home, followed by further assessment in hospital, including a physical examination and blood tests. Results: Of 108 Q‐exposed subjects, 70 (64.8%) had fatigue, 37 idiopathic chronic fatigue (ICF) (34.3%), vs. 29/80 (36.3%) and 12 (15.0%), respectively, in controls. In 77 matched pairs, fatigue was commoner in Q‐exposed subjects than in controls: 50 (64.9%) vs. 27 (35.1%), p<0.0001. ICF was found in 25 (32.5%) of Q‐exposed patients and 11(14.3%) of controls (p=0.01). There were 36 (46.8%) GHQ cases in Q‐exposed subjects, vs. 18 (23.4%) controls (p=0.004). A matched analysis of those more intensively studied showed fatigue in 48 (66.7%) Q‐exposed patients and 25 (34.7%) controls, (p<0.0001), ICF in 25 (34.7%) Q‐exposed and 10 (13.9%) controls (p=0.004), and chronic fatigue syndrome (CFS) in 14 (19.4%) Q‐exposed patients and three (4.2%) controls (p=0.003). Thirty‐four (47.2%) Q‐exposed patients were GHQ cases compared to 17 (23.6%) controls (p=0.004). Discussion: Subjects who were exposed to Coxiella in 1989 had more fatigue than did controls, and some fulfilled the criteria for CFS. Whether this is due to ongoing antigen persistence or to the psychological effects of prolonged medical follow‐up is uncertain.</description><identifier>ISSN: 1460-2725</identifier><identifier>ISSN: 1460-2393</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/95.8.527</identifier><identifier>PMID: 12145392</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Bacterial diseases ; Biological and medical sciences ; Case-Control Studies ; Chronic Disease ; England - epidemiology ; Fatigue - epidemiology ; Fatigue - microbiology ; Female ; Follow-Up Studies ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Q Fever - complications ; Q Fever - epidemiology ; Rickettsial diseases ; Surveys and Questionnaires ; Tropical bacterial diseases ; Tropical medicine</subject><ispartof>QJM : An International Journal of Medicine, 2002-08, Vol.95 (8), p.527-538</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Aug 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-1f8c62c8a739be1094901624b65790694fdf6815eab51895688f52d3cfe172833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13842983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12145392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WILDMAN, M.J.</creatorcontrib><creatorcontrib>SMITH, E.G.</creatorcontrib><creatorcontrib>GROVES, J.</creatorcontrib><creatorcontrib>BEATTIE, J.M.</creatorcontrib><creatorcontrib>CAUL, E.O.</creatorcontrib><creatorcontrib>AYRES, J.G.</creatorcontrib><title>Chronic fatigue following infection by Coxiella burnetii (Q fever): ten‐year follow‐up of the 1989 UK outbreak cohort</title><title>QJM : An International Journal of Medicine</title><addtitle>QJM</addtitle><description>Background: Some patients exposed to Q fever (Coxiella burnetii infection) may develop chronic fatigue. Aim: To determine whether subjects involved in the West Midlands Q fever outbreak of 1989 had increased fatigue, compared to non‐exposed controls, 10 years after exposure. Design: Matched cohort study comparing cases to age‐, sex‐ and smoking‐history‐matched controls not exposed to Q fever. Methods: A postal questionnaire was sent to subjects at home, followed by further assessment in hospital, including a physical examination and blood tests. Results: Of 108 Q‐exposed subjects, 70 (64.8%) had fatigue, 37 idiopathic chronic fatigue (ICF) (34.3%), vs. 29/80 (36.3%) and 12 (15.0%), respectively, in controls. In 77 matched pairs, fatigue was commoner in Q‐exposed subjects than in controls: 50 (64.9%) vs. 27 (35.1%), p<0.0001. ICF was found in 25 (32.5%) of Q‐exposed patients and 11(14.3%) of controls (p=0.01). There were 36 (46.8%) GHQ cases in Q‐exposed subjects, vs. 18 (23.4%) controls (p=0.004). A matched analysis of those more intensively studied showed fatigue in 48 (66.7%) Q‐exposed patients and 25 (34.7%) controls, (p<0.0001), ICF in 25 (34.7%) Q‐exposed and 10 (13.9%) controls (p=0.004), and chronic fatigue syndrome (CFS) in 14 (19.4%) Q‐exposed patients and three (4.2%) controls (p=0.003). Thirty‐four (47.2%) Q‐exposed patients were GHQ cases compared to 17 (23.6%) controls (p=0.004). Discussion: Subjects who were exposed to Coxiella in 1989 had more fatigue than did controls, and some fulfilled the criteria for CFS. Whether this is due to ongoing antigen persistence or to the psychological effects of prolonged medical follow‐up is uncertain.</description><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>England - epidemiology</subject><subject>Fatigue - epidemiology</subject><subject>Fatigue - microbiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Q Fever - complications</subject><subject>Q Fever - epidemiology</subject><subject>Rickettsial diseases</subject><subject>Surveys and Questionnaires</subject><subject>Tropical bacterial diseases</subject><subject>Tropical medicine</subject><issn>1460-2725</issn><issn>1460-2393</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpdkc9uEzEQxleIipbClSOykEBw2NR_1zY3iCgFIiFEKxAXy-vYjdPNOrW90Nz6CH1GngSnWYrEaWY0v_k0n76qeoLgBEFJji6XKzs_kmwiJgzze9UBog2sMZHk_t-eY7ZfPUxpCSGknIoH1T7CiDIi8UG1mS5i6L0BTmd_PljgQteFX74_B7531mQfetBuwDRcedt1GrRD7G32Hrz8Apz9aeOr1yDb_vf1zcbqOJ6XaViD4EBeWICkkODsEwhDbqPVF8CERYj5UbXndJfs47EeVmfH706nJ_Xs8_sP0zez2lCJc42cMA02QnMiW1s8UwlRg2nbMC5hI6mbu0YgZnXLkJCsEcIxPCfGWcSxIOSwerHTXcdwOdiU1cons_XS2zAkxZGkUEpcwGf_gctQzJbfFMaSCUm5KNBkB5kYUorWqXX0Kx03CkG1TUTdJqIkU0KVRMrB01F1aLeLO3yMoADPR0AnozsXdW98-scRQbG89VHvOJ-yvbrb63ihGk44UyfffxTV2bevH0_fKkz-AB0XpFk</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>WILDMAN, M.J.</creator><creator>SMITH, E.G.</creator><creator>GROVES, J.</creator><creator>BEATTIE, J.M.</creator><creator>CAUL, E.O.</creator><creator>AYRES, J.G.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Chronic fatigue following infection by Coxiella burnetii (Q fever): ten‐year follow‐up of the 1989 UK outbreak cohort</title><author>WILDMAN, M.J. ; SMITH, E.G. ; GROVES, J. ; BEATTIE, J.M. ; CAUL, E.O. ; AYRES, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-1f8c62c8a739be1094901624b65790694fdf6815eab51895688f52d3cfe172833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>England - epidemiology</topic><topic>Fatigue - epidemiology</topic><topic>Fatigue - microbiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Q Fever - complications</topic><topic>Q Fever - epidemiology</topic><topic>Rickettsial diseases</topic><topic>Surveys and Questionnaires</topic><topic>Tropical bacterial diseases</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WILDMAN, M.J.</creatorcontrib><creatorcontrib>SMITH, E.G.</creatorcontrib><creatorcontrib>GROVES, J.</creatorcontrib><creatorcontrib>BEATTIE, J.M.</creatorcontrib><creatorcontrib>CAUL, E.O.</creatorcontrib><creatorcontrib>AYRES, J.G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WILDMAN, M.J.</au><au>SMITH, E.G.</au><au>GROVES, J.</au><au>BEATTIE, J.M.</au><au>CAUL, E.O.</au><au>AYRES, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic fatigue following infection by Coxiella burnetii (Q fever): ten‐year follow‐up of the 1989 UK outbreak cohort</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><addtitle>QJM</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>95</volume><issue>8</issue><spage>527</spage><epage>538</epage><pages>527-538</pages><issn>1460-2725</issn><issn>1460-2393</issn><eissn>1460-2393</eissn><abstract>Background: Some patients exposed to Q fever (Coxiella burnetii infection) may develop chronic fatigue. Aim: To determine whether subjects involved in the West Midlands Q fever outbreak of 1989 had increased fatigue, compared to non‐exposed controls, 10 years after exposure. Design: Matched cohort study comparing cases to age‐, sex‐ and smoking‐history‐matched controls not exposed to Q fever. Methods: A postal questionnaire was sent to subjects at home, followed by further assessment in hospital, including a physical examination and blood tests. Results: Of 108 Q‐exposed subjects, 70 (64.8%) had fatigue, 37 idiopathic chronic fatigue (ICF) (34.3%), vs. 29/80 (36.3%) and 12 (15.0%), respectively, in controls. In 77 matched pairs, fatigue was commoner in Q‐exposed subjects than in controls: 50 (64.9%) vs. 27 (35.1%), p<0.0001. ICF was found in 25 (32.5%) of Q‐exposed patients and 11(14.3%) of controls (p=0.01). There were 36 (46.8%) GHQ cases in Q‐exposed subjects, vs. 18 (23.4%) controls (p=0.004). A matched analysis of those more intensively studied showed fatigue in 48 (66.7%) Q‐exposed patients and 25 (34.7%) controls, (p<0.0001), ICF in 25 (34.7%) Q‐exposed and 10 (13.9%) controls (p=0.004), and chronic fatigue syndrome (CFS) in 14 (19.4%) Q‐exposed patients and three (4.2%) controls (p=0.003). Thirty‐four (47.2%) Q‐exposed patients were GHQ cases compared to 17 (23.6%) controls (p=0.004). Discussion: Subjects who were exposed to Coxiella in 1989 had more fatigue than did controls, and some fulfilled the criteria for CFS. Whether this is due to ongoing antigen persistence or to the psychological effects of prolonged medical follow‐up is uncertain.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12145392</pmid><doi>10.1093/qjmed/95.8.527</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1460-2725 |
| ispartof | QJM : An International Journal of Medicine, 2002-08, Vol.95 (8), p.527-538 |
| issn | 1460-2725 1460-2393 1460-2393 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71940992 |
| source | Oxford Journals Online |
| subjects | Bacterial diseases Biological and medical sciences Case-Control Studies Chronic Disease England - epidemiology Fatigue - epidemiology Fatigue - microbiology Female Follow-Up Studies Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Q Fever - complications Q Fever - epidemiology Rickettsial diseases Surveys and Questionnaires Tropical bacterial diseases Tropical medicine |
| title | Chronic fatigue following infection by Coxiella burnetii (Q fever): ten‐year follow‐up of the 1989 UK outbreak cohort |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A02%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20fatigue%20following%20infection%20by%20Coxiella%20burnetii%20(Q%20fever):%20ten%E2%80%90year%20follow%E2%80%90up%20of%20the%201989%20UK%20outbreak%20cohort&rft.jtitle=QJM%20:%20An%20International%20Journal%20of%20Medicine&rft.au=WILDMAN,%20M.J.&rft.date=2002-08-01&rft.volume=95&rft.issue=8&rft.spage=527&rft.epage=538&rft.pages=527-538&rft.issn=1460-2725&rft.eissn=1460-2393&rft_id=info:doi/10.1093/qjmed/95.8.527&rft_dat=%3Cproquest_cross%3E71940992%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c492t-1f8c62c8a739be1094901624b65790694fdf6815eab51895688f52d3cfe172833%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=229589478&rft_id=info:pmid/12145392&rfr_iscdi=true |